Journal article
The relationship between maternal and umbilical cord androgen levels and polycystic ovary syndrome in adolescence: A prospective cohort study
M Hickey, DM Sloboda, HC Atkinson, DA Doherty, S Franks, RJ Norman, JP Newnham, R Hart
Journal of Clinical Endocrinology and Metabolism | ENDOCRINE SOC | Published : 2009
DOI: 10.1210/jc.2009-0544
Abstract
Context: The prenatal antecedents of polycystic ovary syndrome (PCOS) are not known, but prenatal androgen exposure is thought to contribute. This has not previously been investigated in large prospective studies of normal human pregnancy. Objective: The aim of the study was to establish the prospective relationship between early life androgen exposure and PCOS in adolescence. Design and Setting: A prospective cohort study was conducted in the general community. Patients or Other Participants:Atotal of 2900 pregnant women were recruited at 18 wk gestation. Prenatal androgen exposure was measured from maternal blood samples (at 18 and 34-36 wk) and umbilical cord blood. Timed (d 2-5 menstrual..
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Grants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
The collection of maternal data and samples was funded by the Women and Infants' Research Foundation (WIRF), whereas the collection of adolescent data and samples was funded by National Health and Medical Research Council (NHMRC) project Grant 403968 (M. H.). M. H. is also funded by an NHMRC Clinical Career Development Award (no. 404094).